OARSI/OMERACT Initiative to Define States of Severity and Indication for Joint Replacement in Hip and Knee Osteoarthritis. An OMERACT 10 Special Interest Group
Identifieur interne : 006078 ( Main/Exploration ); précédent : 006077; suivant : 006079OARSI/OMERACT Initiative to Define States of Severity and Indication for Joint Replacement in Hip and Knee Osteoarthritis. An OMERACT 10 Special Interest Group
Auteurs : Laure Gossec ; Simon Paternotte ; Clifton O. Bingham ; Daniel O. Clegg ; Philippe Coste ; Philip G. Conaghan ; Aileen M. Davis ; Giampaolo Giacovelli ; Klaus-Peter Gunther ; Gillian Hawker ; Marc C. Hochberg ; Joanne M. Jordan ; Jeffrey N. Katz ; Margreet Kloppenburg ; Arturo Lanzarotti ; Keith Lim ; L. Stefan Lohmander ; Nizar N. Mahomed ; Jean Francis Maillefert ; Rebecca L. Manno ; Lyn M. March ; Steven A. Mazzuca ; Karel Pavelka ; Leonardo Punzi ; Ewa M. Roos ; Lucio C. Rovati ; Helen Shi ; Jasvinder A. Singh ; Maria E. Suarez-Almazor ; Eleonora Tajana-Messi ; Maxime DougadosSource :
- The Journal of Rheumatology [ 0315-162X ] ; 2011.
Abstract
To define pain and physical function cutpoints that would, coupled with structural severity, define a surrogate measure of “need for joint replacement surgery,” for use as an outcome measure for potential structure-modifying interventions for osteoarthritis (OA).
New scores were developed for pain and physical function in knee and hip OA. A cross-sectional international study in 1909 patients was conducted to define data-driven cutpoints corresponding to the orthopedic surgeons’ indication for joint replacement. A post hoc analysis of 8 randomized clinical trials (1379 patients) evaluated the prevalence and validity of cutpoints, among patients with symptomatic hip/knee OA.
In the international cross-sectional study, there was substantial overlap in symptom levels between patients with and patients without indication for joint replacement; indeed, it was not possible to determine cutpoints for pain and function defining this indication. The post hoc analysis of trial data showed that the prevalence of cases that combined radiological progression, high level of pain, and high degree of function impairment was low (2%–12%). The most discriminatory cutpoint to define an indication for joint replacement was found to be [pain (0–100) + physical function (0–100) > 80].
These results do not support a specific level of pain or function that defines an indication for joint replacement. However, a tentative cutpoint for pain and physical function levels is proposed for further evaluation. Potentially, this symptom level, coupled with radiographic progression, could be used to define “nonresponders” to disease-modifying drugs in OA clinical trials.
Url:
DOI: 10.3899/jrheum.110403
PubMed: 21807799
PubMed Central: 3260473
Affiliations:
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Singh</name></author><author><name sortKey="Suarez Almazor, Maria E" sort="Suarez Almazor, Maria E" uniqKey="Suarez Almazor M" first="Maria E." last="Suarez-Almazor">Maria E. 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An OMERACT 10 Special Interest Group</title><author><name sortKey="Gossec, Laure" sort="Gossec, Laure" uniqKey="Gossec L" first="Laure" last="Gossec">Laure Gossec</name></author><author><name sortKey="Paternotte, Simon" sort="Paternotte, Simon" uniqKey="Paternotte S" first="Simon" last="Paternotte">Simon Paternotte</name></author><author><name sortKey="Bingham, Clifton O" sort="Bingham, Clifton O" uniqKey="Bingham C" first="Clifton O." last="Bingham">Clifton O. Bingham</name></author><author><name sortKey="Clegg, Daniel O" sort="Clegg, Daniel O" uniqKey="Clegg D" first="Daniel O." last="Clegg">Daniel O. Clegg</name></author><author><name sortKey="Coste, Philippe" sort="Coste, Philippe" uniqKey="Coste P" first="Philippe" last="Coste">Philippe Coste</name></author><author><name sortKey="Conaghan, Philip G" sort="Conaghan, Philip G" uniqKey="Conaghan P" first="Philip G." last="Conaghan">Philip G. Conaghan</name></author><author><name sortKey="Davis, Aileen M" sort="Davis, Aileen M" uniqKey="Davis A" first="Aileen M." last="Davis">Aileen M. Davis</name></author><author><name sortKey="Giacovelli, Giampaolo" sort="Giacovelli, Giampaolo" uniqKey="Giacovelli G" first="Giampaolo" last="Giacovelli">Giampaolo Giacovelli</name></author><author><name sortKey="Gunther, Klaus Peter" sort="Gunther, Klaus Peter" uniqKey="Gunther K" first="Klaus-Peter" last="Gunther">Klaus-Peter Gunther</name></author><author><name sortKey="Hawker, Gillian" sort="Hawker, Gillian" uniqKey="Hawker G" first="Gillian" last="Hawker">Gillian Hawker</name></author><author><name sortKey="Hochberg, Marc C" sort="Hochberg, Marc C" uniqKey="Hochberg M" first="Marc C." last="Hochberg">Marc C. Hochberg</name></author><author><name sortKey="Jordan, Joanne M" sort="Jordan, Joanne M" uniqKey="Jordan J" first="Joanne M." last="Jordan">Joanne M. Jordan</name></author><author><name sortKey="Katz, Jeffrey N" sort="Katz, Jeffrey N" uniqKey="Katz J" first="Jeffrey N." last="Katz">Jeffrey N. Katz</name></author><author><name sortKey="Kloppenburg, Margreet" sort="Kloppenburg, Margreet" uniqKey="Kloppenburg M" first="Margreet" last="Kloppenburg">Margreet Kloppenburg</name></author><author><name sortKey="Lanzarotti, Arturo" sort="Lanzarotti, Arturo" uniqKey="Lanzarotti A" first="Arturo" last="Lanzarotti">Arturo Lanzarotti</name></author><author><name sortKey="Lim, Keith" sort="Lim, Keith" uniqKey="Lim K" first="Keith" last="Lim">Keith Lim</name></author><author><name sortKey="Lohmander, L Stefan" sort="Lohmander, L Stefan" uniqKey="Lohmander L" first="L. Stefan" last="Lohmander">L. Stefan Lohmander</name></author><author><name sortKey="Mahomed, Nizar N" sort="Mahomed, Nizar N" uniqKey="Mahomed N" first="Nizar N." last="Mahomed">Nizar N. Mahomed</name></author><author><name sortKey="Maillefert, Jean Francis" sort="Maillefert, Jean Francis" uniqKey="Maillefert J" first="Jean Francis" last="Maillefert">Jean Francis Maillefert</name></author><author><name sortKey="Manno, Rebecca L" sort="Manno, Rebecca L" uniqKey="Manno R" first="Rebecca L." last="Manno">Rebecca L. Manno</name></author><author><name sortKey="March, Lyn M" sort="March, Lyn M" uniqKey="March L" first="Lyn M." last="March">Lyn M. March</name></author><author><name sortKey="Mazzuca, Steven A" sort="Mazzuca, Steven A" uniqKey="Mazzuca S" first="Steven A." last="Mazzuca">Steven A. Mazzuca</name></author><author><name sortKey="Pavelka, Karel" sort="Pavelka, Karel" uniqKey="Pavelka K" first="Karel" last="Pavelka">Karel Pavelka</name></author><author><name sortKey="Punzi, Leonardo" sort="Punzi, Leonardo" uniqKey="Punzi L" first="Leonardo" last="Punzi">Leonardo Punzi</name></author><author><name sortKey="Roos, Ewa M" sort="Roos, Ewa M" uniqKey="Roos E" first="Ewa M." last="Roos">Ewa M. Roos</name></author><author><name sortKey="Rovati, Lucio C" sort="Rovati, Lucio C" uniqKey="Rovati L" first="Lucio C." last="Rovati">Lucio C. Rovati</name></author><author><name sortKey="Shi, Helen" sort="Shi, Helen" uniqKey="Shi H" first="Helen" last="Shi">Helen Shi</name></author><author><name sortKey="Singh, Jasvinder A" sort="Singh, Jasvinder A" uniqKey="Singh J" first="Jasvinder A." last="Singh">Jasvinder A. Singh</name></author><author><name sortKey="Suarez Almazor, Maria E" sort="Suarez Almazor, Maria E" uniqKey="Suarez Almazor M" first="Maria E." last="Suarez-Almazor">Maria E. Suarez-Almazor</name></author><author><name sortKey="Tajana Messi, Eleonora" sort="Tajana Messi, Eleonora" uniqKey="Tajana Messi E" first="Eleonora" last="Tajana-Messi">Eleonora Tajana-Messi</name></author><author><name sortKey="Dougados, Maxime" sort="Dougados, Maxime" uniqKey="Dougados M" first="Maxime" last="Dougados">Maxime Dougados</name></author></analytic><series><title level="j">The Journal of Rheumatology</title><idno type="ISSN">0315-162X</idno><idno type="eISSN">0315-162X</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title><p id="P2">To define pain and physical function cutpoints that would, coupled with structural severity, define a surrogate measure of “need for joint replacement surgery,” for use as an outcome measure for potential structure-modifying interventions for osteoarthritis (OA).</p></sec><sec sec-type="methods" id="S2"><title>Methods</title><p id="P3">New scores were developed for pain and physical function in knee and hip OA. A cross-sectional international study in 1909 patients was conducted to define data-driven cutpoints corresponding to the orthopedic surgeons’ indication for joint replacement. A post hoc analysis of 8 randomized clinical trials (1379 patients) evaluated the prevalence and validity of cutpoints, among patients with symptomatic hip/knee OA.</p></sec><sec id="S3"><title>Results</title><p id="P4">In the international cross-sectional study, there was substantial overlap in symptom levels between patients with and patients without indication for joint replacement; indeed, it was not possible to determine cutpoints for pain and function defining this indication. The post hoc analysis of trial data showed that the prevalence of cases that combined radiological progression, high level of pain, and high degree of function impairment was low (2%–12%). The most discriminatory cutpoint to define an indication for joint replacement was found to be [pain (0–100) + physical function (0–100) > 80].</p></sec><sec id="S4"><title>Conclusion</title><p id="P5">These results do not support a specific level of pain or function that defines an indication for joint replacement. However, a tentative cutpoint for pain and physical function levels is proposed for further evaluation. Potentially, this symptom level, coupled with radiographic progression, could be used to define “nonresponders” to disease-modifying drugs in OA clinical trials.</p></sec></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Bingham, Clifton O" sort="Bingham, Clifton O" uniqKey="Bingham C" first="Clifton O." last="Bingham">Clifton O. Bingham</name><name sortKey="Clegg, Daniel O" sort="Clegg, Daniel O" uniqKey="Clegg D" first="Daniel O." last="Clegg">Daniel O. Clegg</name><name sortKey="Conaghan, Philip G" sort="Conaghan, Philip G" uniqKey="Conaghan P" first="Philip G." last="Conaghan">Philip G. Conaghan</name><name sortKey="Coste, Philippe" sort="Coste, Philippe" uniqKey="Coste P" first="Philippe" last="Coste">Philippe Coste</name><name sortKey="Davis, Aileen M" sort="Davis, Aileen M" uniqKey="Davis A" first="Aileen M." last="Davis">Aileen M. Davis</name><name sortKey="Dougados, Maxime" sort="Dougados, Maxime" uniqKey="Dougados M" first="Maxime" last="Dougados">Maxime Dougados</name><name sortKey="Giacovelli, Giampaolo" sort="Giacovelli, Giampaolo" uniqKey="Giacovelli G" first="Giampaolo" last="Giacovelli">Giampaolo Giacovelli</name><name sortKey="Gossec, Laure" sort="Gossec, Laure" uniqKey="Gossec L" first="Laure" last="Gossec">Laure Gossec</name><name sortKey="Gunther, Klaus Peter" sort="Gunther, Klaus Peter" uniqKey="Gunther K" first="Klaus-Peter" last="Gunther">Klaus-Peter Gunther</name><name sortKey="Hawker, Gillian" sort="Hawker, Gillian" uniqKey="Hawker G" first="Gillian" last="Hawker">Gillian Hawker</name><name sortKey="Hochberg, Marc C" sort="Hochberg, Marc C" uniqKey="Hochberg M" first="Marc C." last="Hochberg">Marc C. Hochberg</name><name sortKey="Jordan, Joanne M" sort="Jordan, Joanne M" uniqKey="Jordan J" first="Joanne M." last="Jordan">Joanne M. Jordan</name><name sortKey="Katz, Jeffrey N" sort="Katz, Jeffrey N" uniqKey="Katz J" first="Jeffrey N." last="Katz">Jeffrey N. Katz</name><name sortKey="Kloppenburg, Margreet" sort="Kloppenburg, Margreet" uniqKey="Kloppenburg M" first="Margreet" last="Kloppenburg">Margreet Kloppenburg</name><name sortKey="Lanzarotti, Arturo" sort="Lanzarotti, Arturo" uniqKey="Lanzarotti A" first="Arturo" last="Lanzarotti">Arturo Lanzarotti</name><name sortKey="Lim, Keith" sort="Lim, Keith" uniqKey="Lim K" first="Keith" last="Lim">Keith Lim</name><name sortKey="Lohmander, L Stefan" sort="Lohmander, L Stefan" uniqKey="Lohmander L" first="L. Stefan" last="Lohmander">L. Stefan Lohmander</name><name sortKey="Mahomed, Nizar N" sort="Mahomed, Nizar N" uniqKey="Mahomed N" first="Nizar N." last="Mahomed">Nizar N. Mahomed</name><name sortKey="Maillefert, Jean Francis" sort="Maillefert, Jean Francis" uniqKey="Maillefert J" first="Jean Francis" last="Maillefert">Jean Francis Maillefert</name><name sortKey="Manno, Rebecca L" sort="Manno, Rebecca L" uniqKey="Manno R" first="Rebecca L." last="Manno">Rebecca L. Manno</name><name sortKey="March, Lyn M" sort="March, Lyn M" uniqKey="March L" first="Lyn M." last="March">Lyn M. March</name><name sortKey="Mazzuca, Steven A" sort="Mazzuca, Steven A" uniqKey="Mazzuca S" first="Steven A." last="Mazzuca">Steven A. Mazzuca</name><name sortKey="Paternotte, Simon" sort="Paternotte, Simon" uniqKey="Paternotte S" first="Simon" last="Paternotte">Simon Paternotte</name><name sortKey="Pavelka, Karel" sort="Pavelka, Karel" uniqKey="Pavelka K" first="Karel" last="Pavelka">Karel Pavelka</name><name sortKey="Punzi, Leonardo" sort="Punzi, Leonardo" uniqKey="Punzi L" first="Leonardo" last="Punzi">Leonardo Punzi</name><name sortKey="Roos, Ewa M" sort="Roos, Ewa M" uniqKey="Roos E" first="Ewa M." last="Roos">Ewa M. Roos</name><name sortKey="Rovati, Lucio C" sort="Rovati, Lucio C" uniqKey="Rovati L" first="Lucio C." last="Rovati">Lucio C. Rovati</name><name sortKey="Shi, Helen" sort="Shi, Helen" uniqKey="Shi H" first="Helen" last="Shi">Helen Shi</name><name sortKey="Singh, Jasvinder A" sort="Singh, Jasvinder A" uniqKey="Singh J" first="Jasvinder A." last="Singh">Jasvinder A. Singh</name><name sortKey="Suarez Almazor, Maria E" sort="Suarez Almazor, Maria E" uniqKey="Suarez Almazor M" first="Maria E." last="Suarez-Almazor">Maria E. Suarez-Almazor</name><name sortKey="Tajana Messi, Eleonora" sort="Tajana Messi, Eleonora" uniqKey="Tajana Messi E" first="Eleonora" last="Tajana-Messi">Eleonora Tajana-Messi</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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